Superman vs. Muhammad Ali is an oversize celebrity comic book published by DC Comics in 1978. The 72-page book features Superman teaming up with the heavyweight boxing champion Muhammad Ali to defeat an alien invasion of Earth, a story in which they are required to compete in a boxing match. It was based on an original story by Dennis O'Neil which was adapted by Neal Adams, with pencils by Adams, figure inks by Dick Giordano, and background inks by Terry Austin.

Dennis Joseph O'Neil was an American comic book writer and editor, principally for Marvel Comics and DC Comics from the 1960s through the 1990s, and Group Editor for the Batman family of titles until his retirement.